11. Martel-Pelletier J, Boileau C, Pelletier JP, Roughley PJ: Cartilage in normal and osteoarthritis conditions. Best Pract Res Clin Rheumatol 2008; 22: 351–384

12. McAlindon T, Bartnik E, Ried JS, Teichert L, Herrmann M, Flechsenhar K: Determination of Serum Biomarkers in Patients with Osteoarthritis: A Previous Interventional Imaging Study Revisited. J Biomed Res 2017; 31: 1–6

13. McAlindon TE, Nuite M, Krishnan N et al.: Change in knee osteoarthritis cartilage detected by delayed gadolinium enhanced magnetic resonance imaging following treatment with collagen
hydrolysate: a pilot randomized controlled trial. Osteoarthritis Cartilage 2011; 19: 399–405

14. Moskowitz RW: Role of collagen hydrolysate in bone and joint disease. Semin Arthritis Rheum. 2000; 30: 87–99

15. Nemirovskiy OV, Sunyer T, Aggarwal P et al.: Discovery and development of the N-terminal procollagen type II (NPII) biomarker: a tool for measuring collagen type II synthesis. Osteoarthritis Cartilage 2008; 16: 1494–1500

16. Ng KW, Saliman JD, Lin EY et al.: Culture duration modulates collagen hydrolysate-induced tissue remodelling in chondrocyte-seeded agarose hydrogels. Ann Biomed Eng 2007; 35: 1914–1923

17. Oberschelp U: Individuelle Arthrosetherapie ist möglich. Therapiewoche 1985; 44: 5094–5097

18. Oesser S, Adam M, Babel W, Seifert J: Oral administration of 14C labelled gelatin hydrolysate leads to an accumulation of radioactivity in cartilage of mice (C57/BL). J Nutr 1999; 129: 1891–1895

19. Oesser S, Proksch E, Schunck M: Prophylactic treatment with a special collagen hydrolysate decreases cartilage tissue degeneration in the knee joint. Osteoarthritis Cartilage 2008; 16: 72)

20. Oesser S, Raabe A, Schunck M: Orally administered collagen hydrolysate halts the progression of osteoarthritis in STR/ort mice. Osteoarthritis Cartilage 2008; 16: 72

21. Oesser S, Seifert J: Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen. Cell Tissue Res 2003; 311: 393–399

22. Pereira D, Peleteiro B, Araújo J, Branco J, Santos RA, Ramos E: The effect of osteoarthritis definition on prevalence and incidence estimates: a systematic review. Osteoarthritis Cartilage 2011; 19: 1270–1285

23. Roos EM, Dahlberg L: A four-month, randomized, controlled trial on
glycosaminoglycan content in knee cartilage. Arthritis Rheum 2005: 52: 3507–3514

24. Schadow S, Siebert HC, Lochnit G, Kordelle J, Rickert M, Steinmeyer J:
Collagen metabolism of human osteoarthritic articular cartilage as modulated by bovine collagen hydrolysates. PLoS ONE 8(1): e53955. doi:10.1371 / journal.pone0053955

25. Seeligmüller K, Happel KH: Dem Knorpel auf die Sprünge helfen. Therapiewoche 1993; 43: 1810–1813

26. Tiderius CJ, Olsson LE, Leander P, Ekberg O, Dahlberg L: Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) in early knee osteoarthritis. Magnet Reson Med 2003; 49: 488–492

27. Tiderius CJ, Svensson J, Leander P, Ola T, Dahlberg L: dGEMRIC (delayed gadolinium-enhanced magnetic resonance imaging of cartilage) indicates adaptive capacity of human knee cartilage. Magnet Reson Med 51: 286–290

28. Wirth W, Duryea J, Hellio Le Graverand MP et al. for the OA Initiative Investigators Group: Direct comparison of fixed flexion radiography and MRI in knee osteoarthritis: responsiveness data from the Osteoarthritis Initiative. Osteoarthritis Cartilage 2013; 21: 117–125

29. Zhang W, Robertson J, Jones AC, Dieppe PA, Moherty M: The placebo effect and its determinants in osteoarthritis:
meta-analysis of randomised controlled trials. Ann Rheum Dis 2008; 67: 1716–1723

30. Zuckley L, Angelopoulou K, Carpenter MR: Collagen hydrolysate improves joint function in adults with mild symptoms of osteoarthritis of the knee. Med Sci Sports Exerc 2004; 36 (Supplement), 153–154

Fussnoten

1 TA Immunology Cytokine Modulation, Research and Development, Sanofi Aventis Deutschland GmbH